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2002•Lishizhen Medicine and Materia Medica ResearchRequires access

Effect of Curcumin against CCl_4-Induced Liver Fibrosis in Rats

Jiang Yi-ping

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Abstract

Objective:To investigate the curative effect of curcumin on liver fibrosis in rats induced by CCl 4.Methods:Model of liver fibrosis in rats was induced by CCl 4 by subcutaneous injection of CCl 4 and they were treated with curcumin or malotilate as positive control. The histological changes were observed with microscope. The levels of ALT,AST,NO,HA,LN in serum and Hyp, MDA in liver tissue were determined to reveal the event liver damage.Results:Curcumin significantly reduced the elevate levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue. Pathological examination suggested curcumin has therapeutic effect on experimental liver fibrosis wih significant.Conclusion:Curcumin may have therapeutic effect on CCl 4-induced liver fibrosis in rats.

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What this paper is about

Objective:To investigate the curative effect of curcumin on liver fibrosis in rats induced by CCl 4.Methods:Model of liver fibrosis in rats was induced by CCl 4 by subcutaneous injection of CCl 4 and they were treated with curcumin or malotilate as positive control. The histological changes were observed with microscope. The levels of ALT,AST,NO,HA,LN in serum and Hyp, MDA in liver tissue were determined to reveal the event liver damage.Results:Curcumin significantly reduced the elevate levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue. Pathological examination suggested curcumin has therapeutic effect on experimental liver fibrosis wih significant.Conclusion:Curcumin may have therapeutic effect on CCl 4-induced liver fibrosis in rats.

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Available abstract

Objective:To investigate the curative effect of curcumin on liver fibrosis in rats induced by CCl 4.Methods:Model of liver fibrosis in rats was induced by CCl 4 by subcutaneous injection of CCl 4 and they were treated with curcumin or malotilate as positive control. The histological changes were observed with microscope. The levels of ALT,AST,NO,HA,LN in serum and Hyp, MDA in liver tissue were determined to reveal the event liver damage.Results:Curcumin significantly reduced the elevate levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue. Pathological examination suggested curcumin has therapeutic effect on experimental liver fibrosis wih significant.Conclusion:Curcumin may have therapeutic effect on CCl 4-induced liver fibrosis in rats.

Key concepts: Curcumin, Liver fibrosis, Subcutaneous injection, Pathological, Fibrosis, Medicine, Liver injury, Therapeutic effect

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Effect of Curcumin against CCl_4-Induced Liver Fibrosis in Rats — Research Paper | ScholarLens