Investigation of Xuebijing injection on the treatment of acute respiratory distress syndrome

Objective To investigate the clinical significance and effect of Xuebijing injection on tumor necrosis factor(TNF) and interleukin-8(IL-8) levels in patients with acute respiratory distress syndrome(ARDS).Methods 70 cases of ARDS were randomly divided into two groups.Patients in two groups were treated by routine therapy.Patients in treatment group(n=35) were additionally treated by Xuebijing injection.Patients in control group(n=35) were additionally treated by Dexamethasone sodium phosphate injection.The two groups were treated for 7 consecutive days.Clinical efficacy was analyzed.The levels changes of TNF and IL-8 in two groups were observed 1,3,5,7 days after admission.Results The total effective rate in treatment group and control group was 97.14% and 82.85%,respectively.There was statistically significant between two groups in total effective rate(P0.05).The levels of TNF and IL-8 3,5,7 days after admission were obviously decreased as compared with these 1 day after admission in two groups(P0.05).There was statistically significant between two groups in the levels of TNF and IL-8 3,5,7 days after admission(P0.05).The levels of TNF and IL-8 3,5,7 days after admission in treatment group were lower than those in control group.Conclusion Xuebijing injection can significantly reduce the TNF and IL-8 levels in patients with ARDS,blocking the lung injury process of evolution and promote lung tissue repair and lung function recovery.