Anti-inflammatory and Analgesic Effects of Sophora Flavescens Capsule

Objective To investigate the anti-inflammatory and ianalgesic effects of Sophora Flavescens capsule.Methods Total number of muck in mice with senna-induced diarrhea within 24 h was recorded to observe the influence of Sophora Flavescens capsule,and charcoal-powder method was used to evaluate the effect of Sophora Flavescens capsule on intestinal movement in normal mice.Effects of Sophora Flavescens capsule on pathogens such as Dysentery bacilli,E.coli,Salmonella typhi,and Staphylococcus aureus were determined by the method of broth two-fold dilution.The anti-inflammatory effects were determined in the models of the mouse ear swelling,carrageenin-challenged rat paw edema,as well as the permeability of abdominal capillary in mice,respectively.The analgesic effect was evaluated by the hot plate and the acetic acid induced twist in mice.Results 1 g/kg or 2 g/kg of Sophora flavescens capsules significantly decreased the total number of muck in a dose-dependant manner in mice with senna-induced diarrhea.High and moderate dose of Sophora Flavescens capsule could obviously decrease twist times of the mice.After the mice had been medicated for 60~120 min,Sophora Flavescens capsule(1 and 2 g/kg) significantly prolonged the time that the mice began to lick their hinds after putting into the cylinders.Sophora Flavescens capsule lightened the dimethylxylene-caused mouse ear swelling and carrageenin-challenged paw edema in rats,in a dose-dependent manner.Sophora Flavescens capsule decreased the capillary permeability in abdominal cavity of mice whereas had no influence on peritoneal fluid absorption.The minimal inhibitory concentrations(MIC) of Sophora Flavescens capsule on Dysentery bacilli,E.coli,Salmonella typhi,and Staphylococcus aureus were 1.25 mg/mL,0.625 mg/mL,5 mg/mL,and 5 mg/mL,respectively.Conclusion Sophora Flavescens capsule can reduce diarrhea and small intestinal propulsion,and has analgesic and anti-inflammatory effects.