Effect of atorvastatin on myocardial injure and inflammatory reaction from PCI in patients with unstable angina pectoris

AIM To study the effect of atorvastatin on myocardial injure and inflammatory reaction from percutaneous coronary intervention(PCI)in patients with unstable angina pectoris. The markers of myocardial injure are CK-MB and cardiac troponin (cTnI). The marker of inflammatory reaction is high-sensitivity C-reactive protein (hs-CRP). METHODS The two treatment groups received atorvastatin 20 mg daily or non-atorvastatin 4 successive weeks before PCI,CK-MB,cTnI and hs-CRP of the blood from elbow vein were monitored before and 8 and 24 hours after the procedure of PCI. RESULTS The markers of two groups were elevated after PCI,however,the ascended values of CK-MB,cTnI and hs-CRP in the atrovastatin treatment group were significantly lower than those of the compared group(P0.01). CONCLUSION Administering 20 mg atorvastatin daily in 4 successive weeks before PCI can significantly reduce the myocardial injury and inflammatory reaction.