The effect of different dose atorvastatin therapy before percutaneous coronary intervention on myocardial injury

Objective:To study the effect of different dose atorvastatin in reduction of myocardial injury in patients undergoing early percutaneous coronary intervention(PCI).Methods:A total of 102 patients undergoing PCI with stable angina pectoris(SAP) and unstable angina pectoris(UAP) were randomized to pretreatment with atorvastatin 40mg for 3 days prior to PCI or with a 10mg conventional dose.Creatine kinase-MB(CK-MB),troponin I(cTnI) and high sensitiveity C-reactive protine(hs-CRP) of the blood from elbow vein were measured at baseline and at 8 and 24 hours after the procedure.Creatine kinase(CK) and alanine aminotransferase(ALT) were observed before and after PCI.We also detected the level of cardiac markers from SAP group and UAP group.All the patients were followed 1 month for major adverse cardiac events(MACE).Results:①The level of cTnI and hs-CRP 8 hours after the PCI in the 2 groups were higher than that before the PCI(P0.05).The content of CK-MB was also increased 24 hours after the PCI(P0.05).The levels of post-operative cardiac markers in high-dose atorvastatin group were significantly lower than those in control group(P0.05).The incidences of the elevated cTnI and CK-MB in control group were higher than those in high-dose atorvastatin group(P0.05).②The levels of post-operative hs-CRP and the cardiac markers in high-dose atorvastatin group were significantly lower than those in control group in UAP patients,but only the levels of hs-CRP obvious had difference between 2 group in SAP patients(P0.05).Conclusion:High-dose atorvastatin in 3 successive days before PCI could significantly reduce the myocardial injury.