Perfusion imaging with 64-slice CT in diagnosis of pancreatic cancer

Objective: To assess the feasibility of 64-CT perfusion of normal pancreas and compare the perfusion parameters between normal pancreas and pancreatic cancer. Methods: Twenty-four healthy subjects and 35 patients with pancreatic cancer underwent CT perfusion on a 64-slice CT of Siemens. The raw data was calculated with Siemens software and the perfusion characteristic parameters(including BF, BV, PE, TTP, P) were compared. Results: Pancreatic cancer showed higher P and lower BF, BV and PE compared with those of normal pancreas. Cancer tissue showed lower BF, BV and PE, but higher TTP and P compared with normal tissue in the same patient(P0.05). Pancreatic cancer type 2, 3, 4 showed higher P compared with type 1(P0.05). Conclusion: CT perfusion is a feasible technique to assess pancreatic blood perfusion. Comparation of perfusion parameters of normal tissue and pancreatic cancer tissue of the same patient can be a good option in the diagnosis of pancreatic cancer. Permeability can assess the degree of blood vessels destruction.