The Study of Tumor Perfusion in Pancreatic Carcinoma with 16-Slice Helical CT

Objective:To evaluate the technique and application value of 16 slices spiral-CT perfusion for normal and tumorous pancreas.Methods:Perfusion CT for pancreatic cancer was performed with 16-section multi-detector row CT in 16 patients (all of them were then confirmed by pathology).30 patients with no pancreatic disorders served as controls.Contrast medium-enhanced dynamic CT was performed,and the data were analyzed by using commercial software to calculate tissue blood flow (BF),blood volume (BV),mean transit time (MTT),and vascular permeability-surface (PS) area product.Perfusion parameters of normal pancreas,tumors tissues and the pancreatic tissues near tumors were compared.Results:There were remarkable individual differences between parameters in the CT perfusion:pancreatic cancer showed higher PS and lower BV and BF compared with those of normal pancreas.But there were no significant differences in baseline BF,BV,PS and MTT values between normal pancreas and pancreatic tissues near tumors.However,statistical results showed more significant differences between normal pancreatic tissues and pancreatic cancer tissues.Conclusion:CT perfusion imaging can be used to identify patients with pancreatic carcinomas,because individual differences exist in the results of CT perfusion,and the changes of different parts in the same patient were more significant.