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2010•China Medical HeraldRequires access

Content determination of ginsenoside Rg_1,ginsenoside Rb_1 and notoginsenoside R_1 in Shuxiong Tablets by RP-HPLC

WU Yizhong

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Abstract

Objective:To establish a method for the content determination of ginsenoside Rg1,ginsenoside Rb1 and noto ginsenoside R1 in Shuxiong Tablets by RP-HPLC. Methods:The Shim-pack-C18 (4.6 mm×250 mm,5 μm) column was used. The mobile phases consisted of acetonitrile and water (gradient elution),the flow rate was 1.0 ml/min and the detection wavelength was at 203 nm. Results:The linear ranges of ginsenoside Rg1 was at 0.82-8.20 μg; the linear ranges of ginsenoside Rb1 was at 0.88-8.80 μg; the linear ranges of notoginsenoside R1 was at 0.32-3.20 μg. The average recovery was 99.76% with a RSD of 1.26%. Conclusion:The method is fast,reliable,accurate and can be used in the quality con-trol of ginsenoside Rg1,ginsenoside Rb1 and notoginsenoside in Shuxiong Tablets.

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Objective:To establish a method for the content determination of ginsenoside Rg1,ginsenoside Rb1 and noto ginsenoside R1 in Shuxiong Tablets by RP-HPLC. Methods:The Shim-pack-C18 (4.6 mm×250 mm,5 μm) column was used. The mobile phases consisted of acetonitrile and water (gradient elution),the flow rate was 1.0 ml/min and the detection wavelength was at 203 nm. Results:The linear ranges of ginsenoside Rg1 was at 0.82-8.20 μg; the linear ranges of ginsenoside Rb1 was at 0.88-8.80 μg; the linear ranges of notoginsenoside R1 was at 0.32-3.20 μg. The average recovery was 99.76% with a RSD of 1.26%. Conclusion:The method is fast,reliable,accurate and can be used in the quality con-trol of ginsenoside Rg1,ginsenoside Rb1 and notoginsenoside in Shuxiong Tablets.

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Available abstract

Objective:To establish a method for the content determination of ginsenoside Rg1,ginsenoside Rb1 and noto ginsenoside R1 in Shuxiong Tablets by RP-HPLC. Methods:The Shim-pack-C18 (4.6 mm×250 mm,5 μm) column was used. The mobile phases consisted of acetonitrile and water (gradient elution),the flow rate was 1.0 ml/min and the detection wavelength was at 203 nm. Results:The linear ranges of ginsenoside Rg1 was at 0.82-8.20 μg; the linear ranges of ginsenoside Rb1 was at 0.88-8.80 μg; the linear ranges of notoginsenoside R1 was at 0.32-3.20 μg. The average recovery was 99.76% with a RSD of 1.26%. Conclusion:The method is fast,reliable,accurate and can be used in the quality con-trol of ginsenoside Rg1,ginsenoside Rb1 and notoginsenoside in Shuxiong Tablets.

Key concepts: Ginsenoside Rg1, Ginsenoside, Chromatography, Medicine, Gradient elution, High-performance liquid chromatography, Linear relationship, Content determination

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