2010•Unpublished venueRequires access

Study on determination methods for entrapment efficiency of solid lipid nanoparticles loading huperzine A

Hong Xin Deng

Abstract

Objective To establish a method for the determination of the entrapment efficiency of solid lipid nanoparticles loading huperzine A(Hup A-SLN).Methods The solid lipid nanoparticles and free drugs were separated by ultrafiltration and dialysis with HPLC for the assay of Hup A.Results Free drugs could be effectively separated from the Hup A-SLN by ultrafiltration.The average entrapment efficiency of three batches of Hup A-SLN was 57.63%,with the recovery of 98.09%.Conclusion It convenient,sensitive and accurate with ultrafiltration,and can be used to determine the entrapment efficiency of Hup A-SLN.

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Key concepts: Solid lipid nanoparticle, Huperzine A, Entrapment, Ultrafiltration (renal), Chemistry, Chromatography, Biochemistry, Enzyme