2008•Zhōnghuá yàoxué zázhìRequires access

Determination of Entrapment Efficiency of Paclitaxel Solid Lipid Nanoparticles

Zhou Li

Abstract

OBJECTIVE To establish a HPLC method for the determination of entrapment efficiency of paclitaxel solid lipid nanoparticles(paclitaxel solid lipid nanoparticles,PTX-SLN).METHODS The SLN and free drugs were separated by sephadex filtration,ultracentrifugation and mini-column centrifugation.The methodology study and the optimization of determining condition were carried out.RESULTS Mini-column centrifugation could effectively separate the PTX-SLN from free drugs.The column recovery was 98.23%,the average entrapment efficiency was 94.07%,with RSD of 0.78%.CONCLUSION The method is quick,accurate and feasible.It call be used to determine the entrapment efficiency of PTX-SLN.

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Key concepts: Solid lipid nanoparticle, Entrapment, Chromatography, Chemistry, Centrifugation, Paclitaxel, Sephadex, Filtration (mathematics)