Research on the Effects of Tongxinluo Capsules on Local Cerebral Blood Flow in Patients with Cerebral Infarction

Objective To explore the effects of Tongxinluo capsules on local cerebral blood flow and clinical nerve function defect in patients with cerebral infarction. Methods 31 cases of cerebral infarction were randomly divided into the treatment group of 16 caese treated with Tongxinluo capsules in addition to the routine therapy and the control group of 15 cases treated with the routine therapy. The treatments lasted 20 days in both groups. To explore the changes of local cerebral blood flow, the pathologic changes and the average radioactivity counts in the ROI area of the healthy side mirror image were measured through SPEST ROI technology before and after treatments, all the patients had their nerve function defect evaluated before receiving treatments. Results Decrease in local cerebral blood flow was found in all cases. Improvement of different degrees were got in the area of cerebral blood tlow decrease and the opposite hemisphere mirro image after Tongxinluo was given to these patients. There existed significant differences before and after treatment (P0.01). Evaluations showed that the clinical nerve function defects were also improved (P0.001) after treatment. In the control group, no obvious improvements were got in decrease of blood cerebral flow and clinical nerve function defect before and after routine treatment. Conclusion Tongxinluo capsules can effectively improve the cerebral blood flow and promote the recovery of nerve function in patients with cerebral infarction.