Research on change of syndecan-1 level on surface of placental trophblasts of pregnancy induced hypertension

Objective: To investigate the expression of Syndecan-1 on placental trophoblasts of pregnancy induced hypertension(PIH) so as to explore the pathogenesis of PIH. Methods: Inmmunohistochemistry and computer assisted image processing analysis system were used to detect the expression quantitative evaluation of Syndecan-1 on placenta syncytiotrophoblast in 10 normal pregnancy (control groups) and 30 patients with PIH. Results: In 100% of normal placentas the immunoreactivity with antibody CD138 exhibited very intense staining or intense staining or moderate staining, whereas 53.33% of PIH placentas was negative or week staining and 46.67% of PIH placentas was intense staining or moderate staining. Computer assisted image processing analysis was carried out on average brightness Syndecan-1 staining value of normal placentas and the different degrees (mild, moderate and severe ) of PIH which were 0.474±0.343?0.332±0.109?0.353±0.09 and 0.350±0.068 respectively. There was not difference statistic significantly between the moderate PIH group and the severe PIH group( P 0.05)but statistic significantly between control group and PIH groups( P 0.05).There was statistic significantly between mild PIH group and moderate and severe PIH grorps ( P 0.05). Conclusion: It shows that the reduced expression of Syndecan-1 in placenta syncytiotrophoblast of PIH may be one of the important factors responsible for the pathogenesis of PIH.