Anwei Decoction's Effect on Pathological Changes of Gastric Mucosa and Expression of TFF1mRNA in Rats with Chronic Atrophic Gastritis

OBJECTIVE To explore the effect of Anwei Decoction(AD) on the expression of TFF1mRNAs in rats with chronic atrophic gastritis(CAG).METHODS Forty-eight healthy rats were randomly divided into 4 groups: normal control group,pathologic model group(group A),Anwei Decoction group(group B),and Weifuchun control group(group C).In addition to normal control group,CAG in all of them was induced by N-methy-N-Nit ro-N-Nitroguanidine(MNNG).Pathological changes of gastric mucosa were observed by optical microscope.The effects of drugs on the expression of the two kinds of mRNAs in rats' gastric mucosa were determined by real-time polymerase chain reaction(Real-time PCR).RESULTS In comparison to those in group A,the expression of TFF1mRNA was evidently enhanced in groups B and C(0.86±0.13vs0.54 ±0.10 and 0.83±0.10vs0.54 ±0.10 respectively,P0.01),and the expression of TFF1mRNA was significantly different from those in groups B and C(0.86 ±0.13vs0.83±0.10,P0.01).CONCLUSION Anwei decoction may treat CAG by enhancing the expression of TFF1mRNA in gastric mucosa.