PTEN,P53 and its relationship with endometrial carcinoma

Objective To study the expression and its clinical significance of PTEN and P53 in the pathogensis of endometrial carcinoma methods. Methods A specific and sensitive immunohistoche mical S-P assay was used to detect the expression of PTEN and P53 in paraffin-embedded sections of 20 cases of normal endometrium, endometrial hyperplasia and atypical hyperplasia of endometrial, 50 the tissue near the endometrial carcinoma and endometrial carcinoma. Results The loss expression rates of PTEN in normal proliferative endometrium, endometrial hyperplasia, atypical hyperplasia of endometrial, the tissue near the endometrial carcinoma, and endometrial carcinoma were gradually increased. The difference was significant. The positive rates of the aberrant expressions of P53 was 44%, and the difference was significant. Conclusions PTEN and P53 may play some roles in the carcinogenesis and development of endometrial carcinoma.