The research on the relationship of fibrinogen and carotid atherosclerosis in ischemic stroke patients

Objective To evaluate the relationship of fibrinogen and carotid atherosclerosis in ischemic stroke patients. Methods The ischemic stroke patients underwent Doppler ultrasound examination to detect the intima-media thickness (IMT) and the plaque formation of the common carotid arteries. A blood sample was drawn to evaluate the concentration of fibrinogen. Results One hundred and twenty five ischemic stroke patients were included. There were 40 patients with carotid atherosclerosis, 16 patients with carotid atherosclerosis plaque and 24 patients with increased IMT. The average level of fibrinogen was significantly higher in patients with carotid atherosclerosis than those without carotid atherosclerosis (P0.05). The increase in the incidence of carotid atherosclerosis was associated with the increase in the plasma level of fibrinogen. Conclusion The results of this study showed that the high plasma level of fibrinogen is strongly associated with carotid atherosclerosis in ischemic stroke patients.