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2009•Journal of Oral and Maxillofacial SurgeryRequires access

In vitro Study on the Mechanisms of Arsenic Trioxide (As_2O_3) in the Treatment of Human Adenoid Cystic Carcinoma Cell Line

Yao Sun

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Abstract

Objective: To investigate the biological effects of arsenic trioxide(As2O3) on human adenoid cystic carcinoma cell line in vitro. Methods: The effects of As2O3 on ACC-M and ACC-2 cell lines were investigate in vitro with morphological method,MTT, TUNEL assay and flow cytometry (FCM). Results: The proliferation of cancer cells were inhibited by As2O3 with a time/dose-dependent manner. As2O3 could induce the cell apoptosis of ACC-M and ACC-2 which revealed by TUNEL and FCM. Conclusion: As2O3 can inhibit the growth of human adenoid cystic carcinoma cell line and induce its apoptosis in vitro.

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What this paper is about

Objective: To investigate the biological effects of arsenic trioxide(As2O3) on human adenoid cystic carcinoma cell line in vitro. Methods: The effects of As2O3 on ACC-M and ACC-2 cell lines were investigate in vitro with morphological method,MTT, TUNEL assay and flow cytometry (FCM). Results: The proliferation of cancer cells were inhibited by As2O3 with a time/dose-dependent manner. As2O3 could induce the cell apoptosis of ACC-M and ACC-2 which revealed by TUNEL and FCM. Conclusion: As2O3 can inhibit the growth of human adenoid cystic carcinoma cell line and induce its apoptosis in vitro.

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Available abstract

Objective: To investigate the biological effects of arsenic trioxide(As2O3) on human adenoid cystic carcinoma cell line in vitro. Methods: The effects of As2O3 on ACC-M and ACC-2 cell lines were investigate in vitro with morphological method,MTT, TUNEL assay and flow cytometry (FCM). Results: The proliferation of cancer cells were inhibited by As2O3 with a time/dose-dependent manner. As2O3 could induce the cell apoptosis of ACC-M and ACC-2 which revealed by TUNEL and FCM. Conclusion: As2O3 can inhibit the growth of human adenoid cystic carcinoma cell line and induce its apoptosis in vitro.

Key concepts: Arsenic trioxide, Adenoid cystic carcinoma, Medicine, TUNEL assay, In vitro, Apoptosis, Cell culture, Flow cytometry

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In vitro Study on the Mechanisms of Arsenic Trioxide (As_2O_3) in the Treatment of Human Adenoid Cystic Carcinoma Cell Line — Research Paper | ScholarLens