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2006•Journal of Clinical CardiologyRequires access

Concentration of serum interleukin-10, 18, TNF-α in patients with acute coronary syndrom and its clinical significance

Zhishan Li

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Abstract

Objective:To study the relations of the levels of serum interleukin-18(IL-18), tumor necrosis factor-α(TNF-α) and interleukin-10(IL-10) with acute coronary syndrom(ACS) and their clinical significance. Method:Sixty patients with ACS, including 31 patients with SAP and 55 health persons, were studied. The concentration of serum IL-18,TNFα and IL-10 was measured with ELISA. Result:The levels of serum IL-18 and TNFα in patients with coronary heart disease were significantly higher than those in health persons(P0.01), Whereas the levels of IL-10 were lower(P0.01). Compared with SAP group,ACS group had higher levels of serum IL-18 and TNF-α (P0.01) and lower levels of serum IL-10 (P0.01).Conclusion :The concentration of serum IL-18,TNF-α and IL-10 reflecst the severity and unstable status, thus can be used clinically as a monitor.

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Objective:To study the relations of the levels of serum interleukin-18(IL-18), tumor necrosis factor-α(TNF-α) and interleukin-10(IL-10) with acute coronary syndrom(ACS) and their clinical significance. Method:Sixty patients with ACS, including 31 patients with SAP and 55 health persons, were studied. The concentration of serum IL-18,TNFα and IL-10 was measured with ELISA. Result:The levels of serum IL-18 and TNFα in patients with coronary heart disease were significantly higher than those in health persons(P0.01), Whereas the levels of IL-10 were lower(P0.01). Compared with SAP group,ACS group had higher levels of serum IL-18 and TNF-α (P0.01) and lower levels of serum IL-10 (P0.01).Conclusion :The concentration of serum IL-18,TNF-α and IL-10 reflecst the severity and unstable status, thus can be used clinically as a monitor.

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Available abstract

Objective:To study the relations of the levels of serum interleukin-18(IL-18), tumor necrosis factor-α(TNF-α) and interleukin-10(IL-10) with acute coronary syndrom(ACS) and their clinical significance. Method:Sixty patients with ACS, including 31 patients with SAP and 55 health persons, were studied. The concentration of serum IL-18,TNFα and IL-10 was measured with ELISA. Result:The levels of serum IL-18 and TNFα in patients with coronary heart disease were significantly higher than those in health persons(P0.01), Whereas the levels of IL-10 were lower(P0.01). Compared with SAP group,ACS group had higher levels of serum IL-18 and TNF-α (P0.01) and lower levels of serum IL-10 (P0.01).Conclusion :The concentration of serum IL-18,TNF-α and IL-10 reflecst the severity and unstable status, thus can be used clinically as a monitor.

Key concepts: Medicine, Clinical significance, Tumor necrosis factor alpha, Internal medicine, Coronary heart disease, Interleukin, Tumor necrosis factor α, Serum concentration

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Concentration of serum interleukin-10, 18, TNF-α in patients with acute coronary syndrom and its clinical significance — Research Paper | ScholarLens