Preparation of Fluorouracil-Loaded Chitosan Microspheres Using Ion Cross-linking Technique

5-Fluorouracil-loaded chitosan microspheres were prepared by ion cross-linking technique using chitosan as drug carrier and sodium tripolyphosphate as crosslinker reagent.The morphous of microspheres,the encapsulation efficiency and in vitro release behavior were used to evaluate the influence of different formulations and preparations.The structure of the microspheres was analyzed using scanning electron microscopy,granulometer and infrared spectrum.The results showed that the encapsulation efficiency of 5-fluorouracil-loaded chitosan microspheres was 77.8%.The mean diameter was 6.4 μm,and the initial burst release was 21.3% at 30 min,and the cumulative release was 77.0% within 48 h.The sustained drug release effect was notable in vitro.