Preparation of 5-fluorouracil Loaded Chitosan Sustained-release Microspheres and Drug Release Study in Vitro

Objective To prepare 5-fluorouracil loaded chitosan sustained-release microspheres and to observe the role of sustained-release drugs in vitro.Methods The microspheres were prepared using emulsified-chemical cross-linking method and were studied the microspheres morphology,particle size,drug encapsulation efficiency and the role of drug release in vitro.Results The average particle size of the microspheres was (185.5 ± 15.0)nm,encapsulation efficiency was (49.3±2.1)%,in pH 7.4 PBS buffer solution the cumu lative release percentage of 5-fluorouracil released from microspheres was(61.6±1.8)% on the first day,(78.2±1.6)% on the third day,and(90.5±1.4)% on the seventh day.Conclusion The system of 5-fluorouracil loaded chitosan sustained-release microspheres has good encap-sulation efficiency of drugs and release effect in vitro,consistent with sustain-ned-release preparation of drugs required.