2007•Zhongguo shiyan fangjixue zazhiRequires access

Effect of Jin Kui Gastric Drug in Protecting Experimental Gastric Mucosal Lesion in Rat

Na Yin

Abstract

Objective:To investigate the protective effects of Jin Kui Gastric Drug(JK) on gastric mucosal lesion in rats.Methods:The model of gastric mucosal lesion in rats was induced by aspirin,the indexes of gastric mucosal lesion in experimental groups were observed and determined respectively,the contents of tumour necrosis factor-α(TNF-α),endothelin(ET) and interleukin-1β(IL-1β) in blood serum were measured. Results:The indexes of gastric mucosal lesion after administration of JK was obviously reduced compared with model group.The coutents of TNFα was markedly decreased and the levels of IL-1β was significantly increased. The contents of ET was also reduced,but it showed no difference between JK group and control.Conclusion:JK can protect gastric mucosal lesion in rats and its mechanism may be related to decrease in contents of TNF-α,ET and increase of the IL-1β level.

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Key concepts: Lesion, Medicine, Gastroenterology, Aspirin, Internal medicine, Gastric mucosa, Tumor necrosis factor alpha, Drug