Clinical distribution and antimicrobial resistance analysis of 4 380 pathogenic bacteria in nosocomial infection

Objective To understand clinical distribution and antimicrobial resistance analysis of 4 380 pathogenic bacteria in nosocomial infection.Methods In 2011 the specimens of patients in the class 3A comprehensive hospital were performed by pathogen isolation,identification and antimicrobial susceptibility test according to the routine detection,the result was analyzed by using WHONET 5.6 software.Results The hospital infection rate ranked in the top five departments was neurosurgery,internal medicine,trauma,oncology and ICU;In the 4 380 pathogenic bacterial strains which were isolated from 7 326 clinical specimen,the detection rate of about 59.8%.The gram negative bacilli accounted for 75.3%(3 300/4 380),gram positive cocci accounted for 19.0%(831/4 380),the fungi was 5.7%(249/4 380).The top 10 pathogenic bacteria were as follows:Pseudomonas aeruginosa,Klebsiella pneumoniae,Bauman Acinetobacter,Escherichia coli,Candida albicans,coagulase-negative staphylococci,Staphylococcus aureus,Enterococcus,Enterobacter cloacae and Acinetobacter lwoffii.Methicillin-resistant Staphylococcus aureus(MRSA) positive rate was 49.1%,methicillin resistant coagulase negative staphylococcus(MRCNS) detection rate was 81.2%.Not detected on the glycopeptide resistance in Staphylococcus aureus,extended-spectrum beta-lactamases(ESBLs) of Escherichia coli positive detection rate was 58.9%,ESBLs positive Klebsiella pneumoniae detection rate was 28.9%.Conclusion A variety of factors resulting in patients with low immunity,is conditional pathogenic bacteria caused the main reason of hospital infection;The main pathogen is gram-negative bacilli,including Pseudomonas aeruginosa which is particularly obvious rise,the proportion of fungal infection also has the obvious rise trend.Enterobacteriaceae to carbapenems,amikacin and piperacillin/tazobactam antibiotic resistance rate is relatively low,which shows a trend of multidrug resistance in pseudomonas aeruginosa and acinetobacter bauman.