Pathogenic bacteria distribution and drug resistance analysis of nosocomial infection

Objective To evaluate the distribution and drug resistance of pathogenic bacteria causing nosocomial infection in the hospital.Methods The distribution and drug resistance of pathogenic bacteria isolated from January to November 2009 in the hospital were retrospectively analyzed.Results Among 2827 isolated strains,the main pathogenic bacteria were gram- negative bacilli. The proportion of Pseudomonas aeruginosa,Acinetobacter baumani and Klebsiella pneumoniae was 24.5%,15.7%and 14.0%,respectively. In gram-positive cocci,Staphylococcus aureus and coagulase negative staphylococcus were 11.6%and 5.0%.Against all the ESBLs strains in Klebsiella pneumoniae and Enterobacter coli,penicillin showed the lowest effective rate,ranging from 0.0%to 50.0%.The resistance rate of gram- positive cocci to ceftazidime,imipenem,meropenem,and amikacin was 29.2%,28.8%,28. 1%,and 21.3%,which showed the lowest resistance rates.Conclusions Gram-negative bacilli,especially non-zymophyte,are still the main pathogenic bacteria in the hospital.Moreover,the pathogenic bacteria are multidrug- resistant.It is important to enhance local surveillance of bacterial resistance and characterization of the panresistance mechanism.