Study of long-term effect of nucleoside antiviral drugs in patients with decompensated hepatitis B cirrhosis

Objective To study the effect of nucleoside antiviral(NA)drugs on the liver function and longterm outcomes of patients with decompensated hepatitis B cirrhosis.Methods Patients with decompensated hepatitis B cirrhosis treated in Yunyang County People′s Hospital of Chongqing City were selected from June 2011 to June2013,and divided into control group and antivirus group according to whether received the treatment of NA drugs.The biochemical indicators of liver function and virological indicators of the patients were compared before and after the treatment,and the improvement of the liver function and survival rates of patients with long-term treatment of NA drugs were also analyzed.Results A total of 145 patients were enrolled eventually,including 102 cases in antivirus group and 43 cases in control group.The levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(ALB),cholinesterase(CHE),total bilirubin(TBIL),prothrombin time(PT),liver fibrosis markers(HA and PCⅢ),and HBV DNA of antivirus group before the treatment were significantly different from those after the treatment(P0.05).After 2years of follow-up,the survival analysis results showed that the survival rate of antivirus group was 88.04%,which was significantly higher than control group(55.26%),with statistical difference(χ2=22.437,P0.05).Conclusion NA therapy could significantly increase the survival rate,improve the liver function,and reduce HBV loads of patients with decompensated hepatitis B cirrhosis.