Clinical analysis of infection caused by Pseudomonas aeruginosa

Objective To investigate clinical data,drug resistance and trends of patients infected by Pseudomonas aeruginosa in the hospital and provide a scientific basis for rational clinical use of antimicrobial drugs.Methods The underlying diseases,use of antimicrobial drugs,invasive procedures and antimicrobial susceptibility resistance of 803 Pseudomonas aeruginosa in the hospital were retrospectively analyzed.Results There were 803 Pseudomonas aeruginosa isolated from 247 cases of patients,and the specimens were mainly isolated from sputum.In departments distribution,ICU was the highest,followed by geriatric ward and the neurology ward.Patients often combined with the underlying diseases and had line suctioning,endotracheal intubation,catheterization and other invasive procedures.What the patients used most was piperacillin/cilostazol tazobactam,followed by meropenem and cefoperazone/sulbactam.Drug resistance of Pseudomonas aeruginosa was serious in the hospital,the most sensitive one was polymyxin B,followed by amikacin.The ratios of multi-drug resistant Pseudomonas aeruginosa(MDR-PA) and pan-drug resistant Pseudomonas aeruginosa(PDR-PA) were 88.43% and 10.70% respectively.Conclusion Pseudomonas aeruginosa is isolated mostly in the sputum,commonly happens to the elderly patients and mainly concentrates in the ICU,relates to the patients' serious condition,combining with more underlying diseases,and accepting invasive procedures.Carbapenems should be limited in the clinical use of carbapenems in order to reduce multi-drug resistant Pseudomonas aeruginosa strains.