Effects of Docetaxel,Cisplatin Fluorouracil and Calcium Folinate in Treatment of Patients with Advanced Stomach Cancer

Objective To evaluate the efficacy and toxicity of the combination of docetaxel,5-fluorouracil(5-Fu) and calcium folinate(CF) in the treatment of patients with advanced stomach cancer.Methods Group A: The 52 patients with advanced stomach cancer received Docetaxel 75mg/m2 iv,and 5-Fu 500mg/m2 dl～5iv,CF200mg/m2dl～5iv.Cisplatin﹙DDP﹚20mg/m2 dl～5,A cycle is 3 weeks.Group B: 47 patients received EPI 35mg/m2,DDP,CF 250mg/m2and 5-Fu 425mg/m2.A cycle is 1 weeks and 8 cycles is a course of treatment.Results The overall response rate of Group A was 59.6% and the overall response of the control of Group B was 46.8%.The progression free median duration of responsive patients was 7.8 months in Group A and 6.0 months in Group B.1-and 2-year survival rate in Group A was 51% and 19%,and in Group B were 47% and 9%.There was no obvious difference between overall response rates and 1-year survival rate of two groups(P0.05).The progression free median duration of responsive patients and 2-year survival rate were significantly difference between two groups(P0.05).The major side effects include phlebitis and peripheral neuritis can be accepted by most of the patients.Conclusion Combination of Docetaxel,CF and 5-Fu is an effective regimen in the treatment of patients with advanced stomach cancer.