Docetaxel in combination with S1 in the treatment of patients with advanced gastric cancer

Objective To evaluate the efficacy and toxicity of docetaxel combined with S1 capsule in the treatment of advanced gastric cancer patients.Methods Group A:The 42 patients with advanced gastric cancer were treated with docetaxel 75 mg/m2on day 1 and S1 capsule 80 mg/m2twice day for 14 days.The chemotherapy repeated every 3 weeks.Efficacy and toxicities were evaluated after at least 2 cycles of chemotherapy.Group B :42 patients received Cisplatin(DDP) 25 mg/m2,d 1-3,CF 200 mg/m2,d1-5 iv,5-Fu 500 mg/m2,d1-5,each cycle 4 weeks.Results The overall response rate of Group A was 57.1% and the overall response rate of Group B was 42.9%,Median time to progress(TTP) was 9.3 months in Group A and 6.1 months in Group B,median survival time(MST) was 14.3 months in Group A and 10.2 months in Group B.There was significantly difference between two group(P0.05).The main adverse reactions were leucopenia,nausea and vomiting,which can be tolerated by most of the patients.Conclusion The combination of docetaxel and S1 is well tolerated and effective in the treatment of patients with advanced gastric cancer.