ScholarLens Back to search
2014•Military Medical Journal of South ChinaRequires access

Diagnosis Value of MMP-2 and VEGF Combined Detection in Brain Gliomas

Sui Ru

Open publisher page 0 citations

Abstract

Objective To observe the value of matrix metalloproteinases-2(MMP-2) and vascular endothelial growth factor( VEGF) combined detection in the diagnosis of brain glioma. Methods A total of 90 specimens with brain glioma accepting first time operation in the authors' hospital and confirmed by pathology were selected as glioma group. Another 60 healthy persons were selected as healthy volunteer group. The expression of MMP-2 and VEGF were detected by immunohistochemistry. Results The positive rate of MMP-2 and VEGF in glioma group was significantly higher than that in the healthy group( P 0. 05). MMP-2 and VEGF in glioma group were increased with the increase of the pathological staging( P 0. 05). Conclusion MMP-2 and VEGF combined detection can improve the diagnostic value of brain glioma and is helpful for the early clinical diagnosis.

About this research paper

What this paper is about

Objective To observe the value of matrix metalloproteinases-2(MMP-2) and vascular endothelial growth factor( VEGF) combined detection in the diagnosis of brain glioma. Methods A total of 90 specimens with brain glioma accepting first time operation in the authors' hospital and confirmed by pathology were selected as glioma group. Another 60 healthy persons were selected as healthy volunteer group. The expression of MMP-2 and VEGF were detected by immunohistochemistry. Results The positive rate of MMP-2 and VEGF in glioma group was significantly higher than that in the healthy group( P 0. 05). MMP-2 and VEGF in glioma group were increased with the increase of the pathological staging( P 0. 05). Conclusion MMP-2 and VEGF combined detection can improve the diagnostic value of brain glioma and is helpful for the early clinical diagnosis.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To observe the value of matrix metalloproteinases-2(MMP-2) and vascular endothelial growth factor( VEGF) combined detection in the diagnosis of brain glioma. Methods A total of 90 specimens with brain glioma accepting first time operation in the authors' hospital and confirmed by pathology were selected as glioma group. Another 60 healthy persons were selected as healthy volunteer group. The expression of MMP-2 and VEGF were detected by immunohistochemistry. Results The positive rate of MMP-2 and VEGF in glioma group was significantly higher than that in the healthy group( P 0. 05). MMP-2 and VEGF in glioma group were increased with the increase of the pathological staging( P 0. 05). Conclusion MMP-2 and VEGF combined detection can improve the diagnostic value of brain glioma and is helpful for the early clinical diagnosis.

Key concepts: Glioma, VEGF receptors, Vascular endothelial growth factor, Matrix metalloproteinase, Medicine, Pathological, Immunohistochemistry, Matrix metalloproteinase 9

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Diagnosis Value of MMP-2 and VEGF Combined Detection in Brain Gliomas — Research Paper | ScholarLens