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Expression of VEGF and MMP-7 at Different Levels of Glioma and its Clinical Significance

Weijun Chen

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Abstract

Objective To investigate the expression of VEGF and MMP-7 at different levels of glioma and its clinical significance.Methods The expression of VEGF and MMP-7 in 78 cases of glioma and 10 cases of normal brain tissue was detected by using the immunohistochemistry PV-9000 two step method.Results The expression of VEGF and MMP-7 was negative in the normal brain tissue,and higher expression of VEGF and MMP-7 could be observed with the increasing level of glioma.There was a significant difference in the expression of VEGF and MMP-7 between glioma and normal brain tissue.Conclusion The accumulation of VEGF in cytoplasm can promote the MMP-7 expression,and VEGF and MMP-7 might be associated with the occurrence,development and malignance of glioma,showing the malignant degree,patholgical level and prognosis of glioma.

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Objective To investigate the expression of VEGF and MMP-7 at different levels of glioma and its clinical significance.Methods The expression of VEGF and MMP-7 in 78 cases of glioma and 10 cases of normal brain tissue was detected by using the immunohistochemistry PV-9000 two step method.Results The expression of VEGF and MMP-7 was negative in the normal brain tissue,and higher expression of VEGF and MMP-7 could be observed with the increasing level of glioma.There was a significant difference in the expression of VEGF and MMP-7 between glioma and normal brain tissue.Conclusion The accumulation of VEGF in cytoplasm can promote the MMP-7 expression,and VEGF and MMP-7 might be associated with the occurrence,development and malignance of glioma,showing the malignant degree,patholgical level and prognosis of glioma.

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Available abstract

Objective To investigate the expression of VEGF and MMP-7 at different levels of glioma and its clinical significance.Methods The expression of VEGF and MMP-7 in 78 cases of glioma and 10 cases of normal brain tissue was detected by using the immunohistochemistry PV-9000 two step method.Results The expression of VEGF and MMP-7 was negative in the normal brain tissue,and higher expression of VEGF and MMP-7 could be observed with the increasing level of glioma.There was a significant difference in the expression of VEGF and MMP-7 between glioma and normal brain tissue.Conclusion The accumulation of VEGF in cytoplasm can promote the MMP-7 expression,and VEGF and MMP-7 might be associated with the occurrence,development and malignance of glioma,showing the malignant degree,patholgical level and prognosis of glioma.

Key concepts: Glioma, Medicine, VEGF receptors, Matrix metalloproteinase, Immunohistochemistry, Brain tissue, Clinical significance, Pathology

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Expression of VEGF and MMP-7 at Different Levels of Glioma and its Clinical Significance — Research Paper | ScholarLens