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2005•Journal of Modern StomatologyRequires access

The effect of lanthanum chloride on the interleukin-8 secretion of human gingival fibroblast induced by lipopolysaccharide

Ju Zhang

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Abstract

Objective To evaluate the effect of lanthanum chloride on the interleukin-8(IL-8) secretion of human gingival fibroblast(HGF) induced by lipopolysaccharide(LPS).Methods Human gingival fibroblast was cultured by block methods.ELISA was used to analyze the IL-8 secretion.Results The result of ELISA indicated a significant inhibition effect of LaCl_3 at 1×10~(-4)～1×10~(-6) mol/L on the IL-8 secretion of HGF induced by LPS.Conclusion The results suggest that the resistance function of LaCl_3 against the inflammation may be related to the inhibition effect of LaCl_3 on the release of inflammatory cytokines.

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What this paper is about

Objective To evaluate the effect of lanthanum chloride on the interleukin-8(IL-8) secretion of human gingival fibroblast(HGF) induced by lipopolysaccharide(LPS).Methods Human gingival fibroblast was cultured by block methods.ELISA was used to analyze the IL-8 secretion.Results The result of ELISA indicated a significant inhibition effect of LaCl_3 at 1×10~(-4)～1×10~(-6) mol/L on the IL-8 secretion of HGF induced by LPS.Conclusion The results suggest that the resistance function of LaCl_3 against the inflammation may be related to the inhibition effect of LaCl_3 on the release of inflammatory cytokines.

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Available abstract

Objective To evaluate the effect of lanthanum chloride on the interleukin-8(IL-8) secretion of human gingival fibroblast(HGF) induced by lipopolysaccharide(LPS).Methods Human gingival fibroblast was cultured by block methods.ELISA was used to analyze the IL-8 secretion.Results The result of ELISA indicated a significant inhibition effect of LaCl_3 at 1×10~(-4)～1×10~(-6) mol/L on the IL-8 secretion of HGF induced by LPS.Conclusion The results suggest that the resistance function of LaCl_3 against the inflammation may be related to the inhibition effect of LaCl_3 on the release of inflammatory cytokines.

Key concepts: Lipopolysaccharide, Secretion, Fibroblast, Interleukin, Endocrinology, Internal medicine, Interleukin 6, Lanthanum

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