Changes of C-reactive Protein and Its Clinical Significance in Unstable Angina Pectoris

Objective:To investigate the changes of C-reactive protein(CRP) in patients with unstable angina pectoris(UAP),and to evaluate its clinical significance.Method:The level of CRP in blood was measured in 60 patients with UAP(observed group)and 20 patients with stable angina pectoris(SAP) as controls.Coronary angiography(CAG) was performed in observed group.The changes of CRP in two groups were compared.The relationship between the releasing CRP and clinical conditions,characteristics of coronary artery(CA) in observed group was analysed.Patients in observed group were followed up for 6 months,and the incidence of cardiac events was observed.Results:①The serum level of CRP in observed group was significantly higher than controls(P0.01);②In observed group,the level of CRP increased with clinical Braunwald grade.In group with increasing CRP,the prevalence of complex CA lesions and cardiac events was higher,but the history of angima was shorter than that in group with normal CRP (P0.05,P0.05).Conclusion:①The level of CRP patients in UAP are higher than that of SAP ones.②CAP may be a predictor for conditions,severity of CA lesions and prognosis in UAP.