The clinical observation of sodium glycididazole on enhancement of radiotherapy for nasopharyngeal cancer

Objective To observe the clinical efficacy and adverse reactions of sodium glycididazole( CMNa) for radiotherapy of patients with advanced nasopharyngeal cancer,and to explore the best time and dose of CMNa. Methods 150 patients with advanced nasopharyngeal carcinoma patients were evenly divided into three groups: the control group,CMNa Ⅰ and CMNa Ⅱ. Patients in the control group who received radiotherapy alone. CMNa Ⅰ received CMNa 800mg / m2,30min later,received radiotherapy. CMNa Ⅱ received CMNa 800mg / m2,30 ~ 60 min later,received radiotherapy. Calculations lesions of three groups after radiotherapy were significantly reduced. Results The CR rate( 68. 0%,70. 0%) and efficiency( 100. 0%,96. 0%) of CMNa Ⅰ and Ⅱ were significantly higher than that of the control group( 38. 0%,82. 0%),the difference was statistically significant( P 0. 05). There are no difference of adverse reactions in three groups( P 0. 05). Conclusions CMNa has sensitizing effect of radiotherapy for nasopharyngeal cance. The adverse reactions are not obvious. But after intravenous sodium glycididazole, security of radiotherapy given in 30 ~ 60min seems to be better.