2011•Central South PharmacyRequires access

Antidepressant effect of total saponins from Semen Ziziphi Spinosae

Jinmei Li

Abstract

Objective To observe the antidepressant effect of total saponins from Semen Ziziphi Spinosae in mice.Methods To investigate the antidepressant activity of total saponins from Semen Ziziphi Spinosae by the forced swimming test and tail suspension test,with the immobility time of behavioral despair mice as the indicator.Results Different dose groups of total saponins from Semen Ziziphi Spinosae significantly reduced the immobility time of the mice during the forced swimming test and the tail suspension test(P0.05,P0.01).Conclusion The total saponins from Semen Ziziphi Spinosae have antidepressant effect.

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Key concepts: Semen, Behavioural despair test, Tail suspension test, Antidepressant, Traditional medicine, Pharmacology, Medicine, Internal medicine