2011•Tianjin Journal of Traditional Chinese MedicineRequires access

Study on the antidepressant effect of total flavonoids from Semen Ziziphi Spinosae

Ying Wang

Abstract

[Objective] To observe the antidepressant effect of total flavonoids from Semen Ziziphi Spinosae in mice.[Methods] To investigate the antidepressant activity of total Flavonoids from Semen Ziziphi Spinosae by the forced swimming test and the tail suspension test,with behavioral despair mice in the immobility time as an indicator.[Results] Different dose groups of total flavonoids from Semen Ziziphi Spinosae could significantly reduce the immobility time of mice during the forced swimming test and the tail Suspension test,compared with that of the control group(P0.05);compared with that of the positive group(P0.05).[Conclusion] The total flavonoids from Semen Ziziphi Spinosae possess had significant antidepressant effects.

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Key concepts: Semen, Behavioural despair test, Antidepressant, Tail suspension test, Medicine, Traditional medicine, Pharmacology, Internal medicine