The Changes of proton magnetic resonance spectroscopy (1H-MRS) in substantia nigra and corpus striatum in the patients with Parkinson's disease

Objective To investigate the changes of proton magnetic resonance spectroscopy(MRS)inthe substantia nigra, thalamus and corpus striatum in patients with Parkinsonp's disease (PD); and to evaluate the clinical value of the technique on the pathophysiological process and the diagnose of PD. Methods The content of NAA, Cho and Cr in substantia nigra, thalamus and corpus striatum in 50 patients and 45 age-matched healthy controls were examined with proton MRS. The ratios of NAA/Cr, Cho/Cr and NAA/Cho were calculated. Results The ratio of NAA/ Cr in the substantia nigra in PD patients showed significant reduction compared to the controls. However, no significant differences were found in other ratios in these two areas. Conclusion The reduction of NAA/Cr ratio in substantia nigra in PD patients may indicate the dysfunction of the neurons. Proton MRS may be used as a noninvasive way to diagnose PD and to understand the pathophysiological process of PD.