Expression of Bax and Fas protein in the tissue of hepatocellular carcinoma and its clinical significance

Objective To investigate the roles of the expression of Bax and Fas protein in the incidence and development of hepatocellular carcinoma(HCC)and its significance.Methods The expression of Bax and Fas in HCC and paracancerous tissue from 56 patients were detected by means of immunohistochemistry technique,the correlation between the two indexes and the clinical pathological features of HCC.Results The positive rate of Bax expression in HCC and paracancerous tissue were 66.1%(37/56) and 21.4%(12/56),P0.05(χ2=28.32);The positive rate of Fas expression were 41.1%(23/56) and 80.4%(45/56),P0.05(χ2=21.42).No significant difference was found between the Bax and Fas protein,the two indexes were both correlated with the differentiation of tumor(P0.05),but not associated to age,gender,tumor diameter,hepatic cirrhosis(yes or no)(P0.05).Conclusion The abnormal expression of Bax and Fas protein may take part in the incidence and development of HCC through different ways.