2005•Medical Laboratory SciencesRequires access
Diagnostic value of anti-cyclic citrullinated peptide antibody quantitative analysis in patients with rheumatoid arthritis
Cong Hui
Open publisher page 1 citations
Abstract
Objective To explore the significance of anti-cyclic citrullinated peptide(CCP) antibody in the diagnosis of rheumatoid arthritis. Methods The specificity and sensitivity of anti-CCP were detected by ELISA. The specificity and sensitivity of rheumatoid factor were detected by nephelometry. The relativity between anti-CCP and RF was compared. Results The results were showed significant difference by using anti-cyclic citrullinated petide antibody(P0.01), and the c-detection of anti-cyclic citrullinated peptide antibody and rheumatoid factor can increase sensility and speciality in diagnosing rheumatoid arthritis. Conclusions The CCP antibody has very high specificity. It is not obvious correlation between anti-CCP and rheumatoid factor(r=0.2548, P0.05). Determination of anti-CCP antibody in addition to RF can increase the positive diagnostic rate in RA.