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2011•Chinese Journal of PharmaceuticalsRequires access

Determination of Amlodipine Besylate and Valsartan in Compound Valsartan Tablets by HPLC

Lu D

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Abstract

An HPLC method was established for the determination of amlodipine besylate and valsartan in the compound valsartan tablets.A C18 column was used with the mobile phase of 0.03 mol/L potassium dihydrogen phosphate solution(adjusted to pH 3.0 with 85% phosphoric acid)-methanol(40︰60) at the detection wavelength of 237 nm.The calibration curves of amlodipine besylate and valsartan were linear in the ranges of 3-7 and 48-112 μg/ml.The average recoveries were 99.8% and 99.6%,with RSDs of 1.43% and 1.02%.

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What this paper is about

An HPLC method was established for the determination of amlodipine besylate and valsartan in the compound valsartan tablets.A C18 column was used with the mobile phase of 0.03 mol/L potassium dihydrogen phosphate solution(adjusted to pH 3.0 with 85% phosphoric acid)-methanol(40︰60) at the detection wavelength of 237 nm.The calibration curves of amlodipine besylate and valsartan were linear in the ranges of 3-7 and 48-112 μg/ml.The average recoveries were 99.8% and 99.6%,with RSDs of 1.43% and 1.02%.

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Available abstract

An HPLC method was established for the determination of amlodipine besylate and valsartan in the compound valsartan tablets.A C18 column was used with the mobile phase of 0.03 mol/L potassium dihydrogen phosphate solution(adjusted to pH 3.0 with 85% phosphoric acid)-methanol(40︰60) at the detection wavelength of 237 nm.The calibration curves of amlodipine besylate and valsartan were linear in the ranges of 3-7 and 48-112 μg/ml.The average recoveries were 99.8% and 99.6%,with RSDs of 1.43% and 1.02%.

Key concepts: Valsartan, Amlodipine, Chemistry, Chromatography, Phosphoric acid, High-performance liquid chromatography, Methanol, Potassium

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