Clinical analysis of 924 patients with cervical intraepithelial neoplasia treated by loop electrosurgical excision procedure

Objective To evaluate cervical conization by loop electrosurgical excision procedure (LEEP) in diagnosis and management of cervical intraepithelial neoplasia (CIN).Method From January 2004 to June 2007,924 CIN patients underwent multiple biopsies under colposcope and LEEP at Shanghai First Maternity and Infant Health Care Hospital,whose pathological diagnosis was retrospectively compared and prognosis was analyzed.Results The consistency rate in pathological diagnosis of biopsy and LEEP was 85.50% (790/924). The pathological diagnosis was more severe than multiple biopsies under colposcope in 14.50% (134/924); and less severe in 43.83% (405/924). Four cases (0.43%) of invasive cancer and 19 (2.06%) of CINⅢ involved the gland were diagnosed after LEEP. They are followed up for 6 to 32 months and no recurrence was found. Conclusions Cervical loop electrosurgieal excision procedure (LEEP) conization plays a very important role in diagnosis and treatment of CIN.