Influence of high-dose simvastatin on platelet CD40 ligand expression in patients with acute coronary syndrome

Objective To observe the influence of the early use of high-dose simvastatin on platelet CD40 ligand expression in patients with acute coronary syndrome.Methods Eighty-seven cases of acute coronary syndrome were randomly divided into low-dose simvastatin group(n=46) and high-dose simvastatin group(n=41).The low-dose simvastatin group was given simvastatin 20 mg/d,and the high-dose simvastatin group was given simvastatin 60 mg/d in 24 hours after admission for totally 7 days based on conventional drug therapy.The platelet aggregation rate and platelet CD40 ligand expression were detected before and after treatment.Results After one week,platelet aggregation rate decreased significantly in both groups(P0.05),and decreased more significantly in high-dose simvastatin group((29.4±7.7)%) than that in low-dose simvastatin group((34.2±11.1)%)(P0.05).The platelet CD40 ligand level decreased significantly in two groups after treatment,and decreased more significantly in high-dose simvastatin group(3.07±0.86) than that in low-dose simvastatin group(3.41±0.70)(P0.05).Conclusion The early use of high-dose simvastatin can effectively reduce platelet aggregation rate and platelet CD40 ligand expression in short term in patients with acute coronary syndrome.