Impact of early intensified use of simvastatin treatment on platelet oxidized low-density lipoprotein receptor-1 expression in patients with acute coronary syndrome

Objective:To observe the effect of early intensified use of simvastatin treatment on platelet oxidized low-density lipoprotein receptor-1( LOX-1) expression and short-term prognosis,in patients with acute coronary syndrome. Method:Eighty-seven cases with ACS were randomly divided into A,B group,Patients in A group based on conventional drug therapy was given simvastatin 20 mg/night,patients in B group based on conventional drug therapy was given simvastatin 60 mg/night Blood liver and kidney function,blood sugar,blood lipids,platelet aggregation,platelet expression of LOX-1 was tested on the first day after admission and the day after a week,major cardiovascular events was observed within 30 days after admission.Result:After a week,both groups have decreased platelet aggregation,B group reduced more significantly than A group (34.2±11.1 vs 29.4±7.7,P0.05). The platelet LOX-1 levels were significantly decreased in two groups after treatment too,B group decreased more significantly(2.91±0.65 vs 2.61±0.51,P0.05). Major cardiovascular events within 30 days after admission occurred less in group B.Conclusion:The early intensive simvastatin therapy in patients with acute coronary syndrome can inhibit platelet function and improve short-term prognosis of patients,it may work by inhibiting platelet LOX-1 expression.