Effect of Elective Percutaneous Coronary Intervention on Left Ventricular Remodeling and Systolic Function in Patients After Myocardial Infarction

Objective: To evaluate the effect of elective percutaneous coronary intervention ( PCI) on left ventricular remodeling and systolic function at convalescent stage of acute myocardial infarction. Methods: Retrospective analysis was done among 380 patients with coronary heart disease who had follow-up angiography after successful elective PCI. 224 with a history of myocardial infarction ( MI) were assigned to MI group, and 156 with only angina pectoris to non-Mi group (control). Results:①In non-Mi group, the variables of left ventricular remodeling and systolic function had no significant change after PCI(P0. 05). They were in the normal range.②Before PCI, left ventricular( LV) end-diastolic, end-systolic volume and their indexes(LVEDV,LVEDVI,LVESV,LVESVI) were significantly increased, but LV ejection fraction and end-systolic pressure ( LVEF and LVESP) were significantly decreased ( P 0. 001) in MI group compared with non-Mi group( P 0. 001). During the follow-up LVESV,LVESVI were significantly lowered (P0.001), and SV, SVI, LVEF, LVESP were significantly in-creased( P 0. 05-0. 001) as compared to the baseline, with LVESVI and LVEF more significant in the MI group than in the nonMi group (P0. 05-0. 001). There was no significant difference between anterior and inferior myocardial infarction subgroups (P 0. 05 ).③LVEF was improved after PCI in both infarction-related artery (IRA) occluded group and non-occluded groups ( P 0. 001). LVESV and ESVI were significantly decreased only in the IRA occluded group ( P 0. 05 ). Conclusion: There exist left ventricular remodeling and impaired systolic function in MI patients at convalescent stage. Elective PCI can effectively reverse left ventricular remodeling and improve systolic function.