A Study on the Expression of Multidrug Resistance-Associated Protein Genes in Lung Cancer Tissues and Other Malignant Tumor

Objective To study co-relationally on the expression of multidrug resistance-associated protein (MRP1) genes,lung resistance protein (LRP)genes and proliferating cell antigen Ki-67 in malignant tumor tissues.Methods Immunohistochemistry was used to examine the expression levels of MRP1,LRP and Ki-67 proteins in 110 samples of lung cancer tissues and 22 samples of other malignant tumor tissues (esophageal carcinoma,stomach cancer, bladder cancer, et al )and these expression levels were compared to those of 23 samples of paratumor tissues from the tumor listed above.Results The expression levels of LRP and MRP1 in NSCLC tissues were found remarkably higher than those of paratumor tissues (P0.05).The expression levels of SCLC tissues showed no significant difference from those of paratumor tissues (P0.05), while the expression levels of other miligant tumor tissues were significantly higher than those of paratumor tissues (P0.05).Positive expression was detected in Ki-67 proteins from all of lung cancer and other miligant tumor, and it showed no correlation with that of LRP and MRP1 proteins.Conculusion Multi-drug resistance (MDR) was commonly expressed in NSCLC tissues;MRP1 and LRP are two related proteins involving in MDR. LRP has the highest expression level and may serve as an indicator of the lung caner.The expression levels of LRP and MRP1 protein have no correlation with tumor cell proliferation.