2013•Laboratory Medicine and ClinicRequires access

Differentially diagnostic value of immuno-phenotype in monocyte lineage relative acute myeloid leukemia(M4/M5)

Lin Yuan-fen

Abstract

Objective To study the differentially diagnostic value of CD14,CD11b,CD64and CD4in monocyte lineage relative acute myeloid leukemia(M4/M5).Methods Peripheral blood and bone marrow of 420cases with acute myeloid leukemia was analyzed by flow cytometry.Results In monocyte lineage relative acute myeloid leukemia,the expression percentages of CD14,CD11b,CD64and CD4were 45.4%,46.1%,83.0% and 62.4%,which were significantly higher than patients with non-monocyte lineage relative acute myeloid leukemia(P0.01).CD14and CD11b were with high specificity(100% and 91.8%)and CD64 was with high sensitivity(83.0%).Conclusion Detection of CD14,CD11b,CD64and CD4could be helpful for the differential diagnosis between M4/M5 and other types of acute myeloid leukemia.

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Key concepts: Myeloid leukemia, CD14, CD64, Myeloid, Bone marrow, Monocyte, Medicine, Immunology