Comparison of analgesic effect between dezocine and remifentanil in transabdominal radical resection for rectal cancer

Objective To compare the analgesic effect between dezocine and remifentanil in transabdominal radical resection for rectal cancer. Methods 100 patients scheduled for elective radical resection for rectal cancer of age65- 75 years,American Society of Anesthesiology( ASA) Grade Ⅱ- Ⅲ were randomly assigned into the dezocine group( Group D) and the remifentanil group( Group R). Group D received dezocine 1- 3 μg/( kg·min) intravenously;Group R received remifentanil 0. 1- 0. 3 μg /( kg·min) intravenously. Mean arterial pressure( MAP),heart rate( HR),Narcotrend index,and times of awakening,extubation and discharge from PACU were recorded. Visual Analogue Scale( VAS),Bruggemann Comfort Scale( BCS) and Sedation- Agitation Scale( SAS) were recorded 0 h,1 h,2 h postoperatively. Side effects such as respiratory depression,nausea and vomiting,bradycardia within 48 h postoperatively were also recorded. Results Intraoperative MAP,HR,Narcotrend index were similiar between Groups D and R. Compared with Group R,Group D had a lower MAP and HR during extubation,and had a lower HR 10 minutes after exbutation( P 0. 05),as well as a lower Narcotrend index( P 0. 05). Times elapsed from discontinuation of anesthesia to awakening,extubation and discharge from PACU in Group D were significant increased( P 0. 05). VAS and SAS scores decreased and BCS score increased in Group D( P 0. 05). Respiratory depression rate increased in Group D( P 0. 05). Conclusion Compared with remifentanil,dezocine has a similar analgesic effect in transabdominal radical resection for rectal cancer,and reduced postoperative agitation and hyperalgesia with better perioperative hemodynamic stability. However,more frequent respiratory depression may occur with dezocine.