Clinical research of Dezocine in preventing postoperative hyperalgesia induced by Remifentanil-Sevoflurane anesthesia

Objective To evaluate the effects of Dezocine on postoperative hyperalgesia induced by remifentanil-sevoflurane anesthesia in patients.Methods 120 cases of upper abdominal surgery,ASA Ⅰ or Ⅱ class,aged 18-63 years old,weighing 47-79 kg,were randomly divided into 2 groups(n = 60): Fentanyl group(group F),Dezocine group(group D).Group D received intravenous injection of Dezocine 0.1 mg/kg and group F received intravenous injection of Fentanyl 1 μg/kg at 20 min before the end of surgery.The emergence time(eyes opening time) and extubation time were recorded.Visual analog scale(VAS),bruggrmann comfort scale(BCS) and agitation scale(SAS) at immediately(T0),30 min(T1),60 min(T2) after emergence from anesthesia,and the incidence of respiratory depression,nausea and vomiting,pruritus and urinary retention after extubation were recorded.Results Compared with group F,the emergence time and extubation time were shortened(P 0.05),the incidence of side effects such as respiratory depression,nausea and vomiting and pruritus was decreased in group D(P 0.05).There were no significant differences of VAS,BCS and SAS scores at T0 between the two groups(P 0.05).Compared with T0,VAS and SAS scores were higher and BCS scores were lower at T1,T2 in group F(P 0.05),there were no significant differences of VAS,BCS and SAS scores at any time point in group D(P 0.05).No patients showed urinary retention in both groups.Conclusion Intravenous injection of Dezocine 0.1 mg/kg at 20 min before the end of surgery can reduce postoperative hyperalgesia with little side effects after Remifentanil-Sevoflurane anesthesia in patients.