Comparison of dezocine and fentanyl on hyperalgesia after remifentanil intravenous anesthesia

Objective To investigate the feasibility of dezocine alternative analgesic for remifentanil intravenous anesthesia.Methods 40 patients who were given simple excision of breast lumps using intravenous anesthesia were randomly divided into dezocine group(group A,n=20)and fentanyl group(group B,n=20).The patients of group A were given dezocine 0.1 mg/kg,and the patients of group B were given fentanyl 1 μg/kg intravenously 15 minutes before the completion of the procedure.Results The patients′ consciousness recovery time in group A was lower than that in group B(P0.05),the incidence of respiratory depression,nausea,vomiting during waking up to out of the operating room in group A was significantly lower than that in group B(P0.05).Immediately after awakening there was no significant difference in VAS score between the two groups.From 30 min to 3 h after operation,VAS score of group A was significant lower than that of group B(P0.05).Conclusion Dezocine has good efficacy on hyperalgesia induced by remifentanil intravenous anesthesia.