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2006•Zhongguo jiceng yiyaoRequires access

Clinical study on serum vascular endothelial growth factor in patients with gastric carcinoma

Feng Li-pin

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Abstract

Objective To determine the serum vascular endothelial growth factor(VEGF) level in patients with gastric carcinoma and to analyze its clinical significanceMethods The levels of serum VEGF were measured by ELISA kit(RD,SYSTEM INC,USA) in 50 patients with gastric carcinoma and 30 normal persons as the control group.Results The level of serum VEGF in gastric carcinoma was significantly higher than that of normal control.The level of serum VEGF was positively correlated with tumor size,vessel invasion,lymph-node metastasis.With upgrading of clinical-pathological stage,the level of VEGF increased significantly,but its relation to tumor site,histological type,age,and sex was not significant.Conclusion The level of serum VEGF is closely correlated to invasion and metastasis of gastric carcinoma.Serum VEGF assay may be used to preoperatively predict invasion and metastasis of colorectal carcinoma.

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What this paper is about

Objective To determine the serum vascular endothelial growth factor(VEGF) level in patients with gastric carcinoma and to analyze its clinical significanceMethods The levels of serum VEGF were measured by ELISA kit(RD,SYSTEM INC,USA) in 50 patients with gastric carcinoma and 30 normal persons as the control group.Results The level of serum VEGF in gastric carcinoma was significantly higher than that of normal control.The level of serum VEGF was positively correlated with tumor size,vessel invasion,lymph-node metastasis.With upgrading of clinical-pathological stage,the level of VEGF increased significantly,but its relation to tumor site,histological type,age,and sex was not significant.Conclusion The level of serum VEGF is closely correlated to invasion and metastasis of gastric carcinoma.Serum VEGF assay may be used to preoperatively predict invasion and metastasis of colorectal carcinoma.

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Available abstract

Objective To determine the serum vascular endothelial growth factor(VEGF) level in patients with gastric carcinoma and to analyze its clinical significanceMethods The levels of serum VEGF were measured by ELISA kit(RD,SYSTEM INC,USA) in 50 patients with gastric carcinoma and 30 normal persons as the control group.Results The level of serum VEGF in gastric carcinoma was significantly higher than that of normal control.The level of serum VEGF was positively correlated with tumor size,vessel invasion,lymph-node metastasis.With upgrading of clinical-pathological stage,the level of VEGF increased significantly,but its relation to tumor site,histological type,age,and sex was not significant.Conclusion The level of serum VEGF is closely correlated to invasion and metastasis of gastric carcinoma.Serum VEGF assay may be used to preoperatively predict invasion and metastasis of colorectal carcinoma.

Key concepts: Medicine, Gastric carcinoma, Vascular endothelial growth factor, Pathological, Metastasis, Stage (stratigraphy), VEGF receptors, Internal medicine

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