2012•Modern Diagnosis and TreatmentRequires access
Expression of Survivin and Matrix Metalloproteinase-11 in Gastric Cancer and Its Significance
Zhao Na-na
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Abstract
Objective To study the significance of the expression of survivin and MMP-11 in gastric cancer as well as its relation to tumor invasion and metastasis.Method Through detecting the expression of survivin and MMP-11 in 20 samples of normal gastric mucosa and 60 cases of gastric cancer,the relationship between their expression and clinical pathological characteristics of gastric cancer is discussed.Results The expression of survivin and MMP-11 in gastric cancer tissues and lymph nodes of gastric cancer metastasis was significantly higher than that in normal gastric tissues(P0.05).The expression of survivin was not correlated with patients' age,sex and the degree of tumor differentiation.Survivin positive expression was associated with lymph node metastasis and TNM stage(P0.05).Where as the expression of MMP-11 was not correlated with patients' age,and sex,but was associated with differentiation degree,lymph node metastasis and TNM higher staging(P0.05).The expression of MMP-11 in survivin-positive gastric cancer tissues(86.84%) was higher than that in Survivin-negative tissues(50.00%).Conclusions The expression of survivin and MMP-11 in gastric cancer is correlated in increased expression and the clinical pathological parameters.Guessing survivin may promote invasion and metastasis of gastric cancer through MMP-11,which participate and influence the progress of gastric cancer.