2009•Journal of Clinical Medicine in PracticeRequires access

Effects of high doses of atorvastatin on the expression of matrix metalloproteinase-2 of rat vascular smooth muscle cells

Tao Hu

Abstract

Objective To investigate the adjusting effect of different doses of atorvastatin on Matrix Metalloproteinase-2(MMP-2) expression of rat vascular smooth muscle cell(VSMC).Methods Rat VSMC were cultured in vitro with DMEM containing 10 percent pf calf plasma.Different doses of atorvastatin were added to the VSMC for different groups.The expression of MMP-2 was monitored by enzyme image analysis technique.Results Different doses of atorvastatin could obviously inhibit the activity of MMP-2 dose-dependently.Conclusion Atorvastatin can decrease the expression of MMP-2,and higher dose of atorvastatin can result in more significant inhibitory effect.

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Key concepts: Atorvastatin, Medicine, Matrix metalloproteinase, Vascular smooth muscle, Matrix metalloproteinase 9, Dose dependence, Smooth muscle, In vitro