2008•The Journal of Medical Theory and PracticeRequires access

The Effect of Simvastatin on Thrombolysis in Patients with Unstable Angina Pectoris

Liu Xue-y

Abstract

Objective:To explore the effect of simvastatin on tissue plasminogen activator,plasminogen activator inhibitor(PAI-1) in patients with unstable angia pectoris(UAP).Methods:61 patients with UAP were randomly divided into simvastatin therapeutic group(n=31) and conventional therapeutic group(n=30).Their t-PA,PAI-1 levels were compared respectively before and after treatment.Results:After simvastatin treatment,PAI-1 decreased and there was significant difference,the activity of t-PA had an ascending trend,but no statistical significance.Conclusion:simvastatin can improve thrombolysis significantly in patients with UAP.

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Key concepts: Simvastatin, Medicine, Unstable angina, Thrombolysis, Plasminogen activator, Tissue plasminogen activator, Internal medicine, Therapeutic effect